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The Smac-mimetic peptide promoted degradation of cIAP1 in renal epithelial cells, and in combination with TNF-α, activated receptor interacting serine/threonine kinase 1 (RIPK1) dependent cell death complex, and degradation of the caspase-8 inhibitor, Fas-associated death domain-like interleukin-1-beta-converting enzyme-inhibitory protein long form (FLIP), in cystic renal epithelial cells