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For its part, transforming growth factor β (TGF-β) is one of the major cytokine produced by T cells compared to other body cells, which have a positive effect on cartilage remodeling by upregulating differentiation-related transcription gene Sox9 and downregulating IL-6 receptor expression in chondrocytes, thereby maintaining cartilage homeostasis [9,10]

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In vivo , on the contrary to what was observed following the administration of bioactive end products (6-mercaptopurine and 6-thioguanine), no reduction of circulating white blood cells was observed upon administration of cAVTP and tAVTG (Gunnarsdottir et al., 2002)