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The five symptoms we included in our primary analysis were selected to align with IOM’s core diagnostic criteria for ME/CFS: 1) fatigue or low energy, 2) feeling worse after normal exertion (PEM), 3) POTS, 4) brain fog, and 5) unrefreshing sleep

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In vitro, synovial fibroblasts exposed to GSH reduced IL-6 secretion, suggesting a retreat of synovial inflammation [6]