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Delta (9)-THC-rich extracts impaired memory performance in rats (Fadda et al., 2004[20]), while Δ 9 -THC-induced spatial memory impairment was reversed by cannabinoid CB(1) receptor antagonist, suggesting that the effect of Δ 9 -THC is mediated through cannabinoid CB(1) receptors (Egashira et al., 2012[18])